The Department of Biology is staffed with faculty members who are more than just impassioned mentors and educators; they are well respected leaders in their field. Many of the faculty engage in research. Below is a sampling of some of the varied areas in which Monmouth biology professors apply their theoretical knowledge in the practical world.
Dr. Dottie Lobo, Associate Professor
Signaling pathways need to be tightly controlled to insure that cellular proliferation occurs when needed (for example, during times of wound healing and growth). Our work focuses on the negative regulation of signaling pathways involved in growth control, and how negative regulation of proliferation and apoptosis are aberrantly controlled in cancer. Current research is also focused upon the upstream receptors that control signaling pathways during cell-cell contact, and the differences in the regulation of these receptors in cancer cells and normal cells. We are overexpressing a variety of signaling proteins in cultured cells to determine their potential roles in migration, proliferation, and protection from apoptosis. Students participate in all aspects of this research.
Dr. Michael Palladino, Dean, School of Science, Professor
Damage to spermatozoa as a result of bacterial, yeast, and viral infections of male reproductive organs is known to contribute to male infertility. Yet, relatively little is known about the mechanisms that male reproductive organs use for antimicrobial protection.
The Palladino Lab studies the role of Toll-like receptors (TLRs) in innate immunity of male reproductive organs. TLRs are important mediators of "pathogen-sensing" in innate immune responses and inflammatory actions, and they also play critical roles in adaptive responses to microbial challenge. TLRs comprise a large, evolutionarily conserved family of receptors that mediate innate immunity in a wide range of organisms. Signal activators for TLRs include both gram-positive and gram-negative bacteria, as well as bacterial components including bacterial flagellin, lipoproteins, peptidoglycans, CpG bacterial DNA, and lipopolysaccharides. When activated, TLRs trigger molecular cascades that in turn activate an array of inflammatory responses such as activation of NF-κB as a master regulator of inflammation followed by subsequent release of cytokines, chemokines, and other inflammatory regulators. The goal of our project is to characterize expression patterns for TLRs in male reproductive organs and to examine TLR activation pathways. Students participate in all aspects of research.
Dr. Karen Pesce, Lecturer
The presence of pharmaceutical and personal care products in the environment is of increasing concern; little is known about the possible long-term effects of exposure to these compounds and their bioactive metabolites.
Our work focuses on isolation and investigation of microbial species that can degrade these compounds, which are integral to developing strategies for remediation. Current research includes identifying and characterizing novel microbial genes responsible for degradation of environmental pollutants and molecular profiling of microbial communities. We have isolated bacterial species with the ability to degrade caffeine, N,N-Diethyl-3-methylbenzamide (DEET), ibuprofen, naproxen, and phthalate. Further characterization of these isolates is underway. Students participate in all aspects of this research.
Dr. Dennis Rhoads, Professor
My laboratory models various aspects of adolescent alcohol abuse and the co-use of alcohol and other drugs (e.g., caffeine) as it affects alcohol dependency. Adolescence is a time when many people have their first experience with alcohol and use of alcohol during adolescence may trigger brain changes driving lifelong problems with alcohol abuse.
Janine Mallari (left) and Carlos Rivera (right) displaying nerve-ending fractions prepared by subcellular fractionation of alcoholic brain tissue.
Darsi Pitchon (B.S. Biology, 2009) impresses the judge on her way to an award for best poster at the 2009 Eastern College Science Conference. Darsi presented results on alcohol/caffeine co-addiction, impresses the judge on her way to an award for best poster at the 2009 Eastern College Science Conference. Darsi presented results on alcohol/caffeine co-addiction.
The still-developing brain of adolescents provides a unique combination of targets for alcohol and other drugs. We use a number of different approaches to understand the development of dependence upon alcohol and other drugs and to assess genetic differences that impact susceptibility to developing dependence. These include measuring behavioral responses to acute and chronic drug exposure, monitoring drug consumption and metabolism, and determining levels of specific brain proteins, particularly receptors that are targets for alcohol and other drugs. We are interested in how genetic differences in the starting levels of these proteins affects dependency and also in how these targets change as the adolescent brain adapts to the presence of alcohol and/or other drugs. In this setting, students learn various techniques in neuropharmacology (e.g., drug effects on motor activity and anxiety via computer-controlled activity chambers) and biochemistry (e.g., protein analysis by Western blotting). Examples of recent journal publications with students(*) are:
Dr. John Tiedemann, Assistant Dean, Director of the Marine and Environmental Biology and Policy Program (MEBP)
The beach nesting bird monitoring and stewardship program is one of the projects based in the Tiedemann lab. This program focuses on birds like the piping plover, the least tern, and the greater oystercatcher. The piping plover, a small sandpiper-like bird, nests on coastal beaches from Newfoundland and southeastern Quebec to North Carolina. Once common along the Atlantic coast, piping plover populations were decimated by hunting for the millinery trade in the early twentieth century. Passage of the Migratory Bird Treaty Act in 1918 stopped the hunting of these birds and the Atlantic coast population recovered to some extent. Unfortunately, in the past several decades, the population has declined dramatically as a result of disturbance of nesting habitat and breeding conditions. more...
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